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The defined daily doses (DDD) established by the WHO Collaborating Centre (WHOCC) for Drug Statistics Methodology, permit comparisons of use between different drugs and across different countries

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established the first organoid models from human and mouse endometrium [53, 54]

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Formation of NAPQI adducts on mitochondrial proteins was found to be unique to APAP when compared to its regioisomer 3-hydroxyacetanilide (AMAP), which is non-toxic in mice [24,28,29]